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Associate Director, Director, or Senior Director of Medicinal Chemistry

Avilar Therapeutics is a biopharmaceutical company pioneering the discovery and development of extracellular protein degraders, a new frontier in targeted protein degradation. Avilar develops ATACs (ASGPR Targeting Chimeras), a new class of protein degrader therapeutics that shuttle disease-causing proteins from circulation to the endolysosome where the unwanted proteins are degraded. Avilar has built a proprietary ATAC platform that includes novel, high-affinity, small molecule ASGPR ligands and advanced modeling of the biophysics, pharmacokinetics, and pharmacodynamics of ATAC-mediated endocytosis and degradation. The ATAC platform enables the modular design and synthesis of ATACs extendable across the extracellular proteome to a wide range of proteins involved in the pathogenesis of human diseases. Avilar is leveraging the ATAC platform to create a broad and diverse pipeline of first-in-class extracellular protein degraders. Avilar was founded and financed by RA Capital Management and based in Waltham, MA. For more information, please visit www.avilar-tx.com.

Avilar Therapeutics is seeking an Associate Director, Director, or Senior Director of Medicinal Chemistry with an outstanding record of achievement in drug discovery to advance novel drug candidates into clinical development. The successful candidate will be a highly innovative, motivated, and practical drug-hunting practitioner with demonstrated accomplishments in advancing discovery programs. An entrepreneurial and resilient spirit as well as fearlessness and eagerness to take on a modality agnostic approach to drug discovery is required.

What You Will Do:

  • Lead, develop, and implement medicinal chemistry strategies to discover novel therapeutics that can span multiple modalities (small molecules, peptides, antibody drug conjugates, etc.)
  • Provide subject matter expertise in the field of medicinal chemistry and insight in related disciplines including computational chemistry, drug metabolism, and process development
  • Design high-quality drug candidates with structural, pharmacological, physicochemical, metabolic, and safety considerations
  • Cultivate innovative excellence and think strategically to accomplish project objectives
  • Establish intellectual property strategies with external patent counsel, and lead the preparation of patent documents, peer-reviewed scientific publications, and external scientific presentations
  • Prioritize multi-program chemistry activities and manage/motivate external chemistry partners to achieve program goals efficiently
  • Build, grow, and maintain collaborative and productive relationships with multi-disciplinary internal and external colleagues across biology, chemistry, DMPK, and CMC

What You Must Have:

  • D. in chemistry (organic, medicinal, or a related field) with relevant postdoctoral training
  • 10+ years of drug discovery experience as a medicinal chemist in a pharmaceutical and/or biotechnology setting
  • Strong understanding of all aspects of medicinal chemistry and related disciplines such as biology, computational chemistry, drug metabolism and pharmacokinetics, and process chemistry to advance drug candidates from hit identification through development candidate selection
  • Demonstrated track record of significant contributions to innovative drug discovery projects, exemplified by a consistent record of patent inventorship, peer-reviewed publications, and conference presentations
  • Experience managing external chemistry activities with demonstrated ability to interface effectively with CRO partners
  • Team-oriented, collaborative spirit to motivate and mentor internal colleagues
  • Creative problem-solving skills to meet unforeseen challenges
  • Clear and effective communication style to present project strategy and progress to internal colleagues and external collaborators
  • Ability to make key decisions and manage timelines/resources to advance programs

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