WALTHAM, Mass., November 7, 2022 – Avilar Therapeutics, a biopharmaceutical company focused on extracellular protein degradation, today presented new preclinical proof-of-concept data demonstrating the degradation of extracellular proteins using its asialoglycoprotein receptor (ASGPR) targeting chimera (ATAC) platform at the Keystone Symposium on Targeted Protein Degradation being held in Vancouver, British Columbia. The company presented in vivo proof-of-concept data in non-human primates showing robust and dose-dependent degradation of a circulating extracellular protein by a monovalent ATAC degrader.

“We are excited to present new data in non-human primates demonstrating strong in vivo proof of concept for ATAC-mediated extracellular protein degradation,” said Effie Tozzo, CSO of Avilar Therapeutics. “These compelling data further validate the potential of our ATAC platform and have also directly informed the design and development of our pipeline ATACs targeting serious diseases.”

Highlights of the results presented at the Keystone Symposium include:

  • Avilar’s proprietary small molecule high-affinity ASGPR ligands enabled the synthesis of novel bivalent and monovalent ATAC degraders of Immunoglobulin G (IgG), an abundant and long half-life extracellular protein.
  • In non-human primate repeat-dose studies, both monovalent and bivalent ATACs showed dose-dependent plasma exposure and robust dose-dependent degradation (>80%) of IgG when dosed intravenously.
  • A monovalent ATAC degrader dosed subcutaneously in a non-human primate repeat-dose study demonstrated dose-dependent plasma exposure and equally robust IgG degradation activity as monovalent or bivalent ATACs dosed intravenously.
  • Avilar’s proprietary extracellular degradation modeling simulation technology, customized for ASGPR-mediated uptake and degradation, predicted the dose, dosing regimen, and PK/PD profile of ATACs in vivo.

The poster is available on the Avilar website.

About Avilar Therapeutics

Avilar Therapeutics is a biopharmaceutical company pioneering the discovery and development of extracellular protein degraders, a new frontier in targeted protein degradation. Avilar develops ATACs (ASGPR Targeting Chimeras), a new class of protein degraders that shuttle disease-causing proteins from circulation to the endolysosome where the unwanted proteins are degraded. Avilar has built a proprietary ATAC platform that includes novel, high-affinity, small molecule ASGPR ligands and advanced modeling of the biophysics, pharmacokinetics, and pharmacodynamics of ATAC mediated endocytosis and degradation. The ATAC platform enables the modular design and synthesis of ATACs extendable across the extracellular proteome to a wide range of proteins involved in the pathogenesis of human diseases. Avilar is leveraging the ATAC platform to create a broad and diverse pipeline of first-in-class extracellular protein degraders. Avilar was founded and financed by RA Capital Management and based in Waltham, MA. For more information, please visit www.avilar-tx.com and follow us on Twitter @Avilar_Tx and on LinkedIn.

Media Contact:
Kathryn Morris
The Yates Network
914-204-6412
kathryn@theyatesnetwork.com

WALTHAM, Mass., November 1, 2022 – Avilar Therapeutics, a biopharmaceutical company focused on extracellular protein degradation, today announced it will present preclinical data demonstrating the degradation of extracellular proteins using its asialoglycoprotein receptor (ASGPR) targeting chimeras (ATAC) platform at the Keystone Symposium on Targeted Protein Degradation being held in Vancouver, British Columbia, November 6-8, 2022.

The presentation will include pharmacokinetic (PK) and pharmacodynamic (PD) data from single and repeat-dose studies in non-human primates with monovalent ATAC degraders dosed subcutaneously and intravenously that target immunoglobulin G (IgG), an abundant extracellular protein.

Details of the presentation are as follows:

Title: ASGPR-Targeting Chimeras (ATACs): In Vitro and In Vivo Demonstration of the Degradation of Extracellular Proteins
Poster Number: 1011
Presenting Author: Alison Davis, PhD, Director of Biology
Poster Session Date and Time: Monday November 7, 2022, 7:30-10:00pm PT

The poster will be available on the Avilar website on Monday, November 7.

About Avilar Therapeutics

Avilar Therapeutics is a biopharmaceutical company pioneering the discovery and development of extracellular protein degraders, a new frontier in targeted protein degradation. Avilar develops ATACs (ASGPR Targeting Chimeras), a new class of protein degraders that shuttle disease-causing proteins from circulation to the endolysosome where the unwanted proteins are degraded. Avilar has built a proprietary ATAC platform that includes novel, high-affinity, small molecule ASGPR ligands and advanced modeling of the biophysics, pharmacokinetics, and pharmacodynamics of ATAC mediated endocytosis and degradation. The ATAC platform enables the modular design and synthesis of ATACs extendable across the extracellular proteome to a wide range of proteins involved in the pathogenesis of human diseases. Avilar is leveraging the ATAC platform to create a broad and diverse pipeline of first-in-class extracellular protein degraders. Avilar was founded and financed by RA Capital Management and based in Waltham, MA. For more information, please visit www.avilar-tx.com and follow us on Twitter @Avilar_Tx and on LinkedIn.

Media Contact:
Kathryn Morris
The Yates Network
914-204-6412

kathryn@theyatesnetwork.com

WALTHAM, Mass., October 18, 2022 – Avilar Therapeutics, a biopharmaceutical company focused on extracellular protein degradation, today announced that it will present new in vivo proof-of-concept data from its ATAC (ASGPR Targeting Chimera) degrader platform at two upcoming drug discovery conferences. Kevin Lumb, DPhil, VP Biology, will present at the Discovery on Target Conference being held October 17-20, 2022. Effie Tozzo, PhD, Chief Scientific Officer, will present at the 5th Annual Targeted Protein Degradation Summit being held October 25-28, 2022.

“ATACs offer a promising new approach to protein degradation with the potential to expand the reach of this modality to pathogenic targets outside the cell,” commented Dr. Tozzo. “We are excited to share results from our translational PK/PD studies successfully demonstrating in vivo proof-of-concept for ATAC degraders.”

Data highlights include:

  • In vivo pharmacokinetic and pharmacodynamic data from rodent studies with ATACs targeting Immunoglobulin G (IgG), an abundant extracellular protein
  • In vivo data showing target protein endocytosis via ASGPR in rat hepatocytes and endolysosomal localization and degradation
  • Rapid and robust in vivo protein degradation using ATACs that employ Avilar’s proprietary high-affinity, small molecule ASGPR ligands in a monovalent format
  • In vitro and in vivo data demonstrating the potential for ATACs to selectively degrade specific protein subclasses

Conference presentation details are as follows:

Title: Targeted Degradation of Extracellular Proteins with ATACs (ASGPR-Targeting Chimeras)
Session: Emerging Degrader Modalities
Presenter: Kevin Lumb, DPhil, Vice President, Biology, Avilar Therapeutics
Date and Time: Wednesday, October 19, 8 a.m. ET

Title: Extracellular Protein Targeted Degradation with Novel ATACs (ASGPR Targeting Chimeras)
Session: Spotlighting Emerging Modalities Targeting Extracellular Proteins and Cell Therapy
Presenter: Effie Tozzo, PhD, Chief Scientific Officer, Avilar Therapeutics
Date and Time: Friday, October 28, 11 a.m. ET

The presentations will be available on the Avilar website following the respective conferences.

About Avilar Therapeutics

Avilar Therapeutics is a biopharmaceutical company pioneering the discovery and development of extracellular protein degraders, a new frontier in targeted protein degradation. Avilar develops ATACs (ASGPR Targeting Chimeras), a new class of protein degraders that shuttle disease-causing proteins from circulation to the endolysosome where the unwanted proteins are degraded. Avilar has built a proprietary ATAC platform that includes novel, high-affinity, small molecule ASGPR ligands and advanced modeling of the biophysics, pharmacokinetics, and pharmacodynamics of ATAC mediated endocytosis and degradation. The ATAC platform enables the modular design and synthesis of ATACs extendable across the extracellular proteome to a wide range of proteins involved in the pathogenesis of human diseases. Avilar is leveraging the ATAC platform to create a broad and diverse pipeline of first-in-class extracellular protein degraders. Avilar was founded and financed by RA Capital Management and is based in Waltham, MA. For more information, please visit www.avilar-tx.com and follow us on Twitter @Avilar_Tx and on LinkedIn.

Media Contact:
Kathryn Morris
The Yates Network
914-204-6412
kathryn@theyatesnetwork.com

WALTHAM, Mass., June 15, 2022 – Avilar Therapeutics, a biopharmaceutical company focused on extracellular protein degradation, today announced the appointment of Adam Muzikant, PhD, as Chief Business Officer. Dr. Muzikant brings 18 years of business development experience creating and executing value-creating deals, from platform collaborations to commercial-stage product licenses and M&A, across a range of therapeutic areas and technologies at both private and public biopharmaceutical companies. In his role at Avilar, Dr. Muzikant will be responsible for corporate and business development as well as various business operations functions.

“We are excited to welcome Adam to the Avilar leadership team during this time of significant growth of our company,” said Daniel Grau, CEO and President of Avilar Therapeutics. “He brings exceptional expertise in business development and will play a central role in defining and executing our business, partnering, and financing strategy. Adam’s strong track record of success in establishing diverse partnerships is an ideal fit for Avilar as we build a world-class company focused on extracellular protein degradation.”

“I am thrilled to join the impressive team at Avilar and to help realize the full potential of the company’s innovative ATAC (ASGPR Targeting Chimeras) protein degradation platform and the broad applications of this approach to create new impactful degrader medicines in many therapeutic areas,” said Dr. Muzikant. “I look forward to working in close collaboration with my new colleagues as we strive to make a meaningful difference in the lives of patients suffering from serious diseases.”

Dr. Muzikant joins Avilar after serving as Chief Business Officer of Flexion Therapeutics (NASDAQ: FLXN), where he was instrumental in the sale of the company to Pacira BioSciences for up to $1B in enterprise value. While at Flexion, he was a member of the executive committee and drove construction of a pipeline of novel drug candidates through asset acquisitions, executed a China development and commercialization deal for ZILRETTA®, and orchestrated the R&D efforts of Flexion’s Innovation Lab. Before joining Flexion, Dr. Muzikant was VP Business Development at Synta Pharmaceuticals, where he led the strategic transaction process culminating in a merger with Madrigal Pharmaceuticals. Prior to Synta, he held business development leadership positions at AMAG Pharmaceuticals, Inotek Pharmaceuticals, EPIX Pharmaceuticals, and Predix Pharmaceuticals, and also performed transaction/strategic advisory work at Locust Walk for biotech and pharmaceutical companies. Dr. Muzikant holds a BS in Engineering from the University of California, San Diego and a PhD in Biomedical Engineering from Duke University.

About Avilar Therapeutics

Avilar Therapeutics is a biopharmaceutical company pioneering the discovery and development of extracellular protein degraders, a new frontier in targeted protein degradation. Avilar develops ATACs (ASGPR Targeting Chimeras), a new class of protein degraders that shuttle disease-causing proteins from circulation to the endolysosome where the unwanted proteins are degraded. Avilar has built a proprietary ATAC platform that includes novel, high-affinity, small molecule ASGPR ligands and advanced modeling of the biophysics, pharmacokinetics, and pharmacodynamics of ATAC mediated endocytosis and degradation. The ATAC platform enables the modular design and synthesis of ATACs extendable across the extracellular proteome to a wide range of proteins involved in the pathogenesis of human diseases. Avilar is leveraging the ATAC platform to create a broad and diverse pipeline of first-in-class extracellular protein degraders. Avilar was founded and financed by RA Capital Management and based in Waltham, MA. For more information, please visit www.avilar-tx.com and follow us on Twitter @Avilar_Tx and on LinkedIn.

Media Contact:
Kathryn Morris
The Yates Network
914-204-6412
kathryn@theyatesnetwork.com

WALTHAM, Mass., May 16, 2022 – Avilar Therapeutics, a biopharmaceutical company focused on extracellular protein degradation, today announced the formation of its Scientific Advisory Board (SAB) comprised of an esteemed group of leading scientists with expertise in protein degradation, chemistry, genetics, and drug discovery. The Avilar SAB will provide guidance to the company as it advances the discovery and development of ATACs (ASGPR Targeting Chimeras) as novel degraders of extracellular proteins involved in the pathogenesis of disease. 

The inaugural members of the SAB are:

  • Andrea Ballabio, MD, Director and Founder of the Telethon Institute of Genetics and Medicine and Professor of Medical Genetics, Federico II University and Visiting Professor, Baylor College of Medicine
  • Dan Kahne, PhD, Higgins Professor of Chemistry and Chemical Biology, Harvard University
  • Eric Fischer, PhD, Independent Investigator at Dana-Farber Cancer Institute and Associate Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School
  • David Moller, MD, Chief Scientific Officer, POXEL
  • Michael Rosenzweig, DVM, PhD, Entrepreneur-in-Residence at RA Capital

“We are honored and excited to welcome this group of esteemed scientists and drug discovery experts to our Scientific Advisory Board,” said Daniel Grau, CEO and President of Avilar Therapeutics. “With decades of experience in their respective fields, their counsel will be invaluable to Avilar as we build a pipeline of novel ATAC degraders and continue to advance our technology platform and scientific leadership in extracellular protein degradation.”

Andrea Ballabio, MD
Dr. Ballabio is the founding director of the Telethon Institute of Genetics and Medicine (TIGEM) in Naples, Italy. He is also Professor of Medical Genetics at the University of Naples “Federico II”, Visiting Professor at Baylor College of Medicine in Houston, Texas, and co-founder of CASMA Therapeutics. Previously, he served in the Department of Molecular and Human Genetics of Baylor College of Medicine in Houston where he was Associate Professor and Co-director of the Human Genome Center. Earlier, he worked as a post-doctoral fellow at the Institute of Genetics and Biophysics in Naples and at Guy’s hospital in London UK. He has authored over 350 publications in international peer-reviewed journals. Dr. Ballabio obtained his MD degree and completed his residency in Pediatrics at the University of Naples, Italy.

Dan Kahne, PhD
Dr. Kahne has been directing a research laboratory at Harvard University since 2004. He is a chemist who is recognized for his work studying the mechanisms of antibiotic killing and resistance. He is particularly known for his studies characterizing the proteins that assemble the outer membrane that protects Gram-negative bacteria. This membrane provides intrinsic resistance to most antibiotics which can kill Gram-positive bacteria. This outer membrane prevents drugs from penetrating into the cell so that they can reach their cellular target. Previously, he served on the chemistry faculty at Princeton from 1988 to 2003, after a postdoctoral fellowship at Columbia. He graduated from Cornell University with a degree in art history and chemistry and from Columbia University in 1986 with a PhD in synthetic organic chemistry. Dr. Kahne is a member of the American Academy of Arts and Sciences, American Academy of Microbiology, and the National Academy of Sciences.

Eric Fischer, PhD
Dr. Fischer is an Independent Investigator at Dana-Farber Cancer Institute and Associate Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. He is Director of the Center for Protein Degradation at Dana-Farber Cancer Institute. Dr. Fischer’s research focuses on understanding the molecular architecture, function, and regulation of complex cellular signaling machines and their involvement in cellular processes, as well as leveraging this knowledge to develop new strategies for small-molecule-mediated modulation. Dr. Fischer’s work has significantly contributed to the now widespread use of targeted protein degradation in drug discovery and research. He completed his undergraduate training at the Universities of Hamburg (Germany) and Basel (Switzerland) and completed doctoral training at the Friedrich Miescher Institute for Biomedical Research, also in Basel.

David Moller, MD
Dr. Moller has extensive experience in biopharmaceutical R&D. He currently serves as Chief Scientific Officer (CSO) at POXEL, a clinical stage biopharmaceutical company developing therapeutics for metabolic diseases including rare disorders and non-alcoholic steatohepatitis (NASH). Prior to joining POXEL, he was CSO at Sigilon Therapeutics, a biotechnology company developing a new class of engineered cell-based medicines. Previously, he served in senior R&D and business development roles at Eli Lilly and Merck which led to the launch several new medicines; while on the faculty at Harvard, his laboratory discovered key mechanisms underlying the pathogenesis of metabolic disorders. Dr. Moller has published more than 130 peer-reviewed papers. His honors include election to the American Society of Clinical Investigation, the Association of American Physicians, and appointment as an Adjunct Professor at the Karolinska Institute. He holds an MD from the University of Cincinnati and completed clinical and research training programs at the George Washington and Harvard Universities.

Michael Rosenzweig, DVM, PhD
Dr. Rosenzweig is an entrepreneur-in-residence at RA Capital. He has more than two decades of experience in immuno-oncology and immunology research in both large pharma and biotech settings. Prior to joining RA, Dr. Rosenzweig was Associate Vice President at Merck Research Labs. In this position, he played a critical role in building Merck’s oncology pipeline into one of the most robust in cancer immunotherapy, focusing on a modality-agnostic strategy with a broad biology of targets and Keytruda® combination strategies. He was also responsible for initiating the transition of the autoimmunity strategy from one based on systemic immunosuppression to a targeted immunomodulation approach. Previously, he held discovery leadership roles at Immunext and Tolerx. Dr. Rosenzweig earned a DVM at the University of Pretoria and a PhD in Immunology at the University of Pennsylvania.

About Avilar Therapeutics

Avilar Therapeutics is a biopharmaceutical company pioneering the discovery and development of extracellular protein degraders, a new frontier in targeted protein degradation. Avilar discovers and develops ATACs (ASGPR Targeting Chimeras), a new class of protein degrader therapeutics that shuttle disease-causing proteins from circulation to the endolysosome where the unwanted proteins are degraded. Avilar has built a proprietary ATAC platform that includes novel, high-affinity, small molecule ASGPR ligands and advanced modeling of the biophysics, pharmacokinetics, and pharmacodynamics of ATAC-mediated endocytosis and degradation. The ATAC platform enables the modular design and synthesis of ATACs extendable across the extracellular proteome to a wide range of proteins involved in the pathogenesis of human diseases. Avilar is leveraging the ATAC platform to create a broad and diverse pipeline of first-in-class extracellular protein degraders. Avilar was founded and financed by RA Capital Management and based in Waltham, MA. For more information, please visit www.avilar-tx.com and follow us on Twitter @Avilar_Tx and on LinkedIn.

Media Contact
Kathryn Morris
The Yates Network
914-204-6412
kathryn@theyatesnetwork.com

WALTHAM, Mass., May 3, 2022 – Avilar Therapeutics, a biopharmaceutical company focused on extracellular protein degradation, today announced that members of the company’s leadership team will be featured speakers on advances in the protein degradation field at two upcoming drug discovery conferences.

Effie Tozzo, PhD, Chief Scientific Officer of Avilar, will deliver a keynote address on the topic of extracellular protein degradation at the 9th annual Drug Discovery Strategic Summit being held May 9-10, 2022, in Boston.  Dr. Tozzo’s presentation will describe how the company has developed and integrated a suite of technologies tailored for the design and optimization of ATACs (ASGPR Targeting Chimeras), novel protein degraders that shuttle disease-causing proteins from circulation to the endolysosome where the unwanted proteins are degraded. She will also highlight initial proof-of-concept studies and in vitro characterization of ATAC interactions with ASGPR and target protein, including binding, cellular uptake, and degradation via the endolysosomal pathway.

Daniel Grau, Chief Executive Officer and President of Avilar, will participate in a panel session on novel protein degraders at the 33rd annual Cancer Progress Conference being held virtually on May 10-12, 2022.

Details of the keynote address and panel session are as follows:

——————————————————

Keynote Address: Extracellular Protein Targeted Degradation with Novel ATACs (ASGPR Targeting Chimeras

Event: 9th annual Drug Discovery Strategic Summit being held May 9-10, 2022, Boston

Date:  Monday, May 9, 2022, 1:20 p.m. ET

——————————————————

Panel Session: Degraders and Beyond: The Rise of Diverse Heterobifunctional Molecules

Event: 33rd Annual Cancer Progress Conference (virtual)

Date: Wednesday, May 11, 2022, 3:30 p.m. ET

About Avilar Therapeutics

Avilar Therapeutics is a biopharmaceutical company pioneering the discovery and development of extracellular protein degraders, a new frontier in targeted protein degradation. Avilar develops ATACs (ASGPR Targeting Chimeras), a new class of protein degraders that shuttle disease-causing proteins from circulation to the endolysosome where the unwanted proteins are degraded. Avilar has built a proprietary ATAC platform that includes novel, high-affinity, small molecule ASGPR ligands and advanced modeling of the biophysics, pharmacokinetics, and pharmacodynamics of ATAC mediated endocytosis and degradation. The ATAC platform enables the modular design and synthesis of ATACs extendable across the extracellular proteome to a wide range of proteins involved in the pathogenesis of human diseases. Avilar is leveraging the ATAC platform to create a broad and diverse pipeline of first-in-class extracellular protein degraders. Avilar was founded and financed by RA Capital Management and based in Waltham, MA. For more information, please visit www.avilar-tx.com and follow us on Twitter @Avilar_Tx and on LinkedIn.

Media Contact:
Kathryn Morris
The Yates Network
914-204-6412

kathryn@theyatesnetwork.com

WALTHAM, Mass., April 19, 2022 – Avilar Therapeutics, a biopharmaceutical company focused on extracellular protein degradation, today announced a scientific poster presentation highlighting ATACs (ASGPR-Targeting Chimeras) at the 5th annual Protein Degradation Using PROTACs & Molecular Glues meeting being held in San Diego, April 19-20. ATACs are a new class of degraders designed to degrade extracellular proteins,

ATACs are bi-functional molecules comprising a ligand that binds to a target protein, conjugated to a second ligand that binds to the asialoglycoprotein receptor (ASGPR). ATACs work by binding to and shuttling disease-causing proteins from circulation to the hepatocyte endolysosome, where the unwanted proteins are degraded. The presentation will highlight initial ATAC platform proof-of-concept studies with ATACs designed to target extracellular proteins with different concentration and kinetic properties. In vitro characterization of the ATAC interactions with ASGPR and the target proteins, including binding, cellular uptake, and degradation via the endolysosomal pathway, will be presented.

“With nearly 40% of proteins located outside the cell, and many having a clearly defined role in the pathogenesis of human diseases, the ability to target extracellular proteins for degradation is a major step forward for this powerful new drug modality,” said Effie Tozzo, PhD, Chief Scientific Officer of Avilar. “With our novel ATAC discovery platform that enables us to selectively degrade pathogenic extracellular proteins, we are creating new and innovative medicines to treat multiple serious diseases.”

Details of the poster presentation are as follows:

Presentation Title: ASGPR-Targeting Chimeras (ATACs): A New Class of Degraders for Targeting Extracellular Proteins

Authors: Srinivasa Karra, Alison Davis, Jessica Friedman, Ron de Jong, Jesse Chen, Kevin Lumb, Jason Wiles

Session Date: Tuesday, April 19 – Wednesday, April 20

About Avilar Therapeutics

Avilar Therapeutics is a biopharmaceutical company pioneering the discovery and development of extracellular protein degraders, a new frontier in targeted protein degradation. Avilar develops ATACs (ASGPR Targeting Chimeras), a new class of protein degraders that shuttle disease-causing proteins from circulation to the endolysosome where the unwanted proteins are degraded. Avilar has built a proprietary ATAC platform that includes novel, high-affinity, small molecule ASGPR ligands and advanced modeling of the biophysics, pharmacokinetics, and pharmacodynamics of ATAC mediated endocytosis and degradation. The ATAC platform enables the modular design and synthesis of ATACs extendable across the extracellular proteome to a wide range of proteins involved in the pathogenesis of human diseases. Avilar is leveraging the ATAC platform to create a broad and diverse pipeline of first-in-class extracellular protein degraders. Avilar was founded and financed by RA Capital Management and based in Waltham, MA. For more information, please visit www.avilar-tx.com and follow us on Twitter @Avilar_Tx and on LinkedIn.

Media Contact:
Kathryn Morris
The Yates Network
914-204-6412
kathryn@theyatesnetwork.com

WALTHAM, Mass., March 14, 2022 – Avilar Therapeutics, a biopharmaceutical company focused on extracellular protein degradation, today announced that Daniel Grau, CEO and President, will present at the upcoming Guggenheim Targeted Protein Degradation Day at 2:00PM – 2:30PM on Wednesday, March 16, 2022. The format of the day will consist of analyst-led panel discussions with companies and experts on a series of topics in targeted protein degradation including the current status and future outlook for therapeutics across oncology, inflammation, neurology, and other potential areas.

About Avilar Therapeutics

Avilar Therapeutics is a biopharmaceutical company pioneering the discovery and development of extracellular protein degraders, a new frontier in targeted protein degradation. Avilar develops ATACs (ASGPR Targeting Chimeras), a new class of protein degrader therapeutics that shuttle disease-causing proteins from circulation to the endolysosome where the unwanted proteins are degraded. Avilar has built a proprietary ATAC platform that includes novel, high-affinity, small molecule ASGPR ligands and advanced modeling of the biophysics, pharmacokinetics, and pharmacodynamics of ATACmediated endocytosis and degradation. The ATAC platform enables the modular design and synthesis of ATACs extendable across the extracellular proteome to a wide range of proteins involved in the pathogenesis of human diseases. Avilar is leveraging the ATAC platform to create a broad and diverse pipeline of first-inclass extracellular protein degraders. Avilar was founded and financed by RA Capital Management and based in Waltham, MA. For more information, please visit www.avilar-tx.com and follow us on Twitter @Avilar_Tx and on LinkedIn.

Media Contact

Kathryn Morris, The Yates Network
914-204-6412
kathryn@theyatesnetwork.com

WALTHAM, Mass., November 18, 2021 – Avilar Therapeutics, a biopharmaceutical company focused on extracellular protein degradation, today announced a $60 million seed financing from founding investor RA Capital Management. Avilar is creating a novel class of protein degrader therapeutics designed to target disease-causing extracellular proteins, extending the reach of protein degradation beyond initial degraders that target intracellular proteins.

Avilar has built a proprietary technology platform to develop novel extracellular protein degraders called ATACs, or ASGPR Targeting Chimeras. ATACs harness a natural process through which endogenous proteins are internalized into hepatocytes via the asialoglycoprotein receptor (ASGPR) and degraded. Designed as bi-functional molecules, ATACs comprise a ligand that binds to a target protein, conjugated to a second ligand that binds to ASGPR. ATACs work by binding to and shuttling disease-causing proteins from circulation to the hepatocyte endolysosome, where the unwanted proteins are degraded.

“We believe the universe of extracellular proteins represents the next frontier in protein degradation and we are excited to launch Avilar as a pioneer company in this new space,” said Daniel Grau, CEO and President of Avilar Therapeutics. “Avilar has demonstrated in vivo proof-of-concept of ATAC-mediated protein degradation in both rodent and nonhuman primate studies, and we look forward to advancing ATACs as novel medicines to degrade proteins involved in the pathogenesis of a wide range of human diseases.”

Proceeds from the $60 million financing have been allocated to developing Avilar’s ATAC degrader platform and to systematically applying this platform to create a pipeline of ATAC therapeutics.

“RA Capital has deep experience in the protein degradation field based on our investments to date in intracellular degradation companies such as Arvinas, C4 Therapeutics, Frontier Medicines, and Vividion. We are thrilled to now launch Avilar to go beyond intracellular degradation and establish a leading position in the extracellular protein degradation field,” said Josh Resnick, M.D., Managing Director at RA Capital and a member of the Avilar Board of Directors.

Proprietary ATAC Technology Platform for Extracellular Protein Degradation

Avilar’s proprietary technology platform enables the modular design and synthesis of ATACs to target diverse extracellular proteins. Key components of the ATAC technology platform include:

  • Novel ASGPR Chemistries: Avilar has deployed an X-ray structure guided approach to discover a library of small molecule, high-affinity ASGPR ligands that offer monovalent functionality and superior properties.
  • Modular Assembly: Avilar’s optimized small molecule ASGPR ligands are modular and can be efficiently incorporated into ATACs with different protein binders to target a wide range of disease-causing extracellular proteins.
  • Extracellular Degradation Modeling: Avilar has developed specialized mathematical modeling tools to integrate and simulate the unique biophysical, pharmacokinetic, and pharmacodynamic characteristics of ATAC-mediated endocytosis and degradation.
  • Proteome Mapping: Avilar has created a protein informatics system that extensively catalogues extracellular protein information to enable advanced insights for target selection, protein binder design, and ATAC therapeutic development.

Avilar is leveraging this technology platform to target disease-causing extracellular proteins that are either inadequately addressed or previously undruggable using current drug modalities.

Experienced Avilar Team of Biopharma Business and Science Leaders

“Avilar is well positioned with an exceptional team of biopharmaceutical executives and scientific leaders with the skills and experience to build a rich pipeline of first-in-class ATAC degraders. We look forward to working with the Avilar team to build a world-class extracellular degradation company,” said Tess Cameron, Principal at RA Capital and member of the Avilar Board of Directors.

The Avilar team of seasoned biopharmaceutical executives and leading scientists includes:

  • Daniel Grau, MPhil, CEO and President (Sojournix, Heptares)
  • Effie Tozzo, PhD, Chief Scientific Officer (Cellarity, Mitobridge/Astellas, Merck, Roche)
  • Phil Graham, PhD, Chief Development Officer (Sojournix, Concert, EPIX, Lilly)
  • Jason Wiles, PhD, VP Preclinical Development (Alexion, Achillion)
  • Kevin Lumb, PhD, VP Biology (Janssen, Bayer, Merck)

The Avilar Board of Directors includes:

  • Milind Deshpande, PhD, Chairman (Achillion, BMS, Spero)
  • Daniel Grau, MPhil, CEO and President (Sojournix, Heptares)
  • Josh Resnick, MD, Board Director (RA Capital)
  • Tess Cameron, Board Director (RA Capital)
  • Marty Freed, MD, Board Director (Dicerna, Solid, GSK)

Avilar was founded at RA Capital by an experienced team of drug hunters, including Milind Deshpande, PhD (Venture Partner), Jesse Chen, PhD (Entrepreneur in Residence), Nathaniel Horwitz, and Jamie Kasuboski, PhD, supported by a team of leading chemists and experts in lysosomal biology.

About Avilar Therapeutics

Avilar Therapeutics is a biopharmaceutical company pioneering the discovery and development of extracellular protein degraders, a new frontier in targeted protein degradation. Avilar develops ATACs (ASGPR Targeting Chimeras), a new class of protein degrader therapeutics that shuttle disease-causing proteins from circulation to the endolysosome where the unwanted proteins are degraded. Avilar has built a proprietary ATAC platform that includes novel, high-affinity, small molecule ASGPR ligands and advanced modeling of the biophysics, pharmacokinetics, and pharmacodynamics of ATAC-mediated endocytosis and degradation. The ATAC platform enables the modular design and synthesis of ATACs extendable across the extracellular proteome to a wide range of proteins involved in the pathogenesis of human diseases. Avilar is leveraging the ATAC platform to create a broad and diverse pipeline of first-inclass extracellular protein degraders. Avilar was founded and financed by RA Capital Management and based in Waltham, MA. For more information, please visit www.avilar-tx.com.

About RA Capital Management

RA Capital Management is a multi-stage investment manager dedicated to evidence-based investing in public and private healthcare and life science companies that are developing drugs, medical devices, and diagnostics. The flexibility of its strategy allows RA Capital to provide seed funding to startups and to lead private, IPO, and follow-on financings for its portfolio companies, allowing management teams to drive value creation from inception through commercialization. For more information, please visit www.racap.com.